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quinupristin/dalfopristin will raise the level or effect of sparsentan by affecting hepatic/intestinal enzyme CYP3A4 metabolism.quinupristin/dalfopristin will increase the level or impact of acalabrutinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Intently. Decrease acalabrutinib dose to 100 mg when day-